crac channel blocker synta compound 66 (Synta Inc)
90
Structured Review
Synta Inc
crac channel blocker synta compound 66
Crac Channel Blocker Synta Compound 66, supplied by Synta Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/crac+channel+blocker+synta+compound+66/synta+66/pm30773908-217-14-17
Average 90 stars, based on 1 article reviews
Crac Channel Blocker Synta Compound 66, supplied by Synta Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/crac+channel+blocker+synta+compound+66/synta+66/pm30773908-217-14-17
Average 90 stars, based on 1 article reviews
crac channel blocker synta compound 66 - by Bioz Stars,
2026-10
90/100 stars
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other:Article Title: Identification of potential CRAC channel inhibitors: Pharmacophore mapping, 3D-QSAR modelling, and molecular docking approach. Article Snippet: Upregulation of store-operated Ca influx via ORAI1, an integral component of the CRAC channel, is responsible for abnormal cytokine release in active rheumatoid arthritis, and therefore ORAI1 has been proposed as an attractive molecular target.. In this study, we attempted to predict the mechanical insights of ORAI1 inhibitors through pharmacophore modelling, 3D-QSAR, molecular docking and free energy analysis.. Various hypotheses of pharmacophores were generated and from that, a pharmacophore hypothesis with two hydrogen bond acceptors, one hydrogen bond donor and two aromatic rings (AADRR) resulted in a statistically significant 3D-QSAR model (r = 0.84 and q = 0.74). Isolation:Article Title: Store-operated CRAC channels: function in health and disease. Article Snippet: | Elevation of cytosolic Ca levels through the activation of store-operated Ca release-activated Ca (CRAC) channels is involved in mediating a disparate array of cellular responses.. These include secretion, metabolism and gene expression, as well as cell growth and proliferation.. Moreover, emerging evidence points to the involvement of aberrant CRAC channel activity in human diseases, such as certain types of immunodeficiency and autoimmunity disorders, allergy, and inflammatory bowel disease. |